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El Nov 20, 2003 10:33 am, Text-Conference November 17 dijo:
[22:35] (MJesus> I introduce you Dr. Anders Hellden ...
[22:36] (Hellden> Hello dear nephrologists! I would like to give you some
background on acyclovir-induced CNS-symptoms.
[22:41] (Speaker> ______ _____________ resumed ____________
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[22:41] (MJesus> thanks dr. Hellden --- question or commentary for?
[22:43] (MJesus> have you much experience in treartment of herpes encephalitis ?
[22:43] (gtorres> can be prevented the precipitation of ganciclovir?
[22:45] (Hellden> We have not performed any studies in patients with herpes encephalitis. But we ave helped the clinicians to make descisions whether to perform a hemodialysis or not.
[22:46] (Hellden> Dr Torres. Could you be more specific?
[22:48] (gtorres> the crystallization in the tubules of ganciclovir can be prevented?
[22:50] (Hellden> I do not know about ganciclovir precipitation. Precipitation by acyclovir can be prevented by hydration and slow intravenous infusion.
[22:52] (MJesus> what are the consequences of this precipitation? stones ?
[22:52] (gtorres> expansion of volume, like all the tubular toxics?
[22:52] (Hellden> Patients with sever renal failure should have very low doses of oral acyclovir.
[22:54] (Hellden> Expansion of volume is good unless you have ESRD with the risk for volume overload.
[22:54] (gtorres> thanks
[22:54] (MJesus> thanks you...
[22:54] (Hellden> My pleasure
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